2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N12360
    2,3-Dehydrosilybin A 25166-14-7 98%
    2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound.
    2,3-Dehydrosilybin A
  • HY-N12531
    Molephantin 50656-66-1 98%
    Molephantin is a blood-brain barrier permeable anti-glioblastoma compound. Molephantin induces ROS generation, leading to mitochondrial damage, Mitophagy flux blockage and Apoptosis induction. Molephantin can suppress the PI3K/Akt/mTOR signaling pathway. Molephantin demonstrates antitumor effects against glioblastoma.
    Molephantin
  • HY-N12696
    Cistanoside H 104806-92-0
    Cistanoside H is a phenylethanoid glycoside neuroprotective agent that can be isolated from the leaves and twigs of Callicarpa dichotoma. Cistanoside H can alleviate glutamate-induced oxidative stress and protect rat cortical cells from neurotoxic damage. Cistanoside H protects nerve cells against excitotoxic damage and can be applied in research related to neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease).
    Cistanoside H
  • HY-N12768
    Rhodojaponin VI 37720-87-9 98%
    Rhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G. Don
    (Ericaceae) (RM). Rhodojaponin VI binds rat N-Ethylmaleimide-sensitive fusion (NSF) with a Kd of 1.03 μM. Rhodojaponin VI blocks the MDM2-Notch1 signalling pathway by reducing MDM2 and Notch1 expression. Rhodojaponin VI indirectly reduces Cav2.2 current intensity by inhibiting NSF-mediated Cav2.2 trafficking. Rhodojaponin VI alleviates glomerulonephritis progression and podocyte injury in passive heymann nephritis rats. Rhodojaponin VI also has antinociceptive effects. Rhodojaponin VI can be used for the researches of heymann nephritis and pain.
    Rhodojaponin VI
  • HY-N13041
    Acacetin 7-O-(6-O-malonylglucoside) 155049-92-6 98%
    Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values ​​of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders.
    Acacetin 7-O-(6-O-malonylglucoside)
  • HY-N13061
    Nervon 17283-91-9 98%
    Nervon is a crystalline cerebroside. Nervon can be used for the research of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.
    Nervon
  • HY-N13170
    Glycoside H2 73529-43-8 98%
    Glycoside H2 is a potentiator of NGF-mediated nerve fiber outgrowth.
    Glycoside H2
  • HY-N1318R
    Salvigenin (Standard) 19103-54-9 98%
    Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis.
    Salvigenin (Standard)
  • HY-N13293
    Isopaynantheine 22032-51-5 98%
    Isopaynantheine (3-Isopaynantheine), an alkaloid, is an opioid. Isopaynantheine has antinociceptive activity in mice.
    Isopaynantheine
  • HY-N13902
    Arisugacin B 182068-83-3 98%
    Arisugacin B is a potent, orally active and selective acetylcholinesterase (AChE) inhibitor.
    Arisugacin B
  • HY-N13923
    Arisugacin C 261950-90-7 98%
    Arisugacin C is an acetylcholinesterase (AChE) inhibitor with an IC50 of 2.5 μM.
    Arisugacin C
  • HY-N13924
    Arisugacin D 261950-94-1 98%
    Arisugacin D is an acetylcholinesterase (AChE) inhibitor with an IC50 of 3.5 μM.
    Arisugacin D
  • HY-N13925
    Arisugacin E 261951-22-8 98%
    Arisugacin E, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin E shows no activity against AChE.
    Arisugacin E
  • HY-N13926
    Arisugacin F 261951-44-4 98%
    Arisugacin F, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin F shows no activity against AChE.
    Arisugacin F
  • HY-N13927
    Arisugacin G 261951-57-9 98%
    Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE.
    Arisugacin G
  • HY-N13928
    Arisugacin H 261951-59-1 98%
    Arisugacin H, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin H shows no activity against AChE.
    Arisugacin H
  • HY-N13992
    Barbamide 174630-03-6 98%
    Barbamide is found in the strain of Lyn-gbya majiuscula that has the activity of killing mollusks.
    Barbamide
  • HY-N1412R
    1,3-Dicaffeoylquinic acid (Standard) 19870-46-3
    1,3-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,3-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.
    1,3-Dicaffeoylquinic acid (Standard)
  • HY-N14218
    Eurystatin A 137563-63-4 98%
    Eurystatin A is a prolyl endopeptidase inhibitor, L-Leucine and L-Ornithine are the direct precursors of the L-Leucine and L-Ornithine moieties of eurystatins A.
    Eurystatin A
  • HY-N14226
    Eurystatin B 137563-64-5 98%
    Eurystatin B is a prolyl endopeptidase (PED) inhibitor. Eurystatin B has a protective effect during Scopolamine (HY-N0296)-induced amnesia in rats.
    Eurystatin B
Cat. No. Product Name / Synonyms Application Reactivity